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The structure of the ternary Eg5–ADP–ispinesib complex
The human kinesin Eg5 is responsible for bipolar spindle formation during early mitosis. Inhibition of Eg5 triggers the formation of monoastral spindles, leading to mitotic arrest that eventually causes apoptosis. There is increasing evidence that Eg5 constitutes a potential drug target for the deve...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
International Union of Crystallography
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3447400/ https://ncbi.nlm.nih.gov/pubmed/22993085 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444912027965 |
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