Force and Premature Binding of ADP Can Regulate the Processivity of Individual Eg5 Dimers

Using a high-resolution optical trapping instrument, we directly observed the processive motions of individual Eg5 dimers over a range of external loads and ATP, ADP, and phosphate concentrations. To constrain possible models for dissociation from the microtubule, we measured Eg5 run lengths and als...

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Bibliografske podrobnosti
Main Authors: Valentine, Megan T., Block, Steven M.
Format: Artigo
Jezik:Inglês
Izdano: The Biophysical Society 2009
Teme:
Muscle, Motility, and Motor Proteins
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2749793/
https://ncbi.nlm.nih.gov/pubmed/19751672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.07.013
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