The Therapeutic Profile of Rolipram, PDE Target and Mechanism of Action as a Neuroprotectant following Spinal Cord Injury

The extent of damage following spinal cord injury (SCI) can be reduced by various neuroprotective regimens that include maintaining levels of cyclic adenosine monophosphate (cyclic AMP), via administration of the phosphodiesterase 4 (PDE4) inhibitor Rolipram. The current study sought to determine th...

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Autors principals: Schaal, Sandra Marie, Garg, Maneesh Sen, Ghosh, Mousumi, Lovera, Lilie, Lopez, Michael, Patel, Monal, Louro, Jack, Patel, Samik, Tuesta, Luis, Chan, Wai-Man, Pearse, Damien Daniel
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446989/
https://ncbi.nlm.nih.gov/pubmed/23028463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043634
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