Severe Acute Respiratory Syndrome Coronavirus Replication Is Severely Impaired by MG132 due to Proteasome-Independent Inhibition of M-Calpain

The ubiquitin-proteasome system (UPS) is involved in the replication of a broad range of viruses. Since replication of the murine hepatitis virus (MHV) is impaired upon proteasomal inhibition, the relevance of the UPS for the replication of the severe acute respiratory syndrome coronavirus (SARS-CoV...

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Main Authors: Schneider, Martha, Ackermann, Kerstin, Stuart, Melissa, Wex, Claudia, Protzer, Ulrike, Schätzl, Hermann M., Gilch, Sabine
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2012
Assuntos:
Virus-Cell Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446591/
https://ncbi.nlm.nih.gov/pubmed/22787216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01001-12
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