CCR5 Mutations Distinguish N-Terminal Modifications of RANTES (CCL5) with Agonist versus Antagonist Activity

CCR5 is the major HIV-1 entry coreceptor. RANTES/CCL5 analogs are more potent inhibitors of infection than native chemokines; one class activates and internalizes CCR5, one neither activates nor internalizes, and a third partially internalizes without activation. Here we show that mutations in CCR5...

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Detalhes bibliográficos
Main Authors: Choi, Won-Tak, Nedellec, Rebecca, Coetzer, Mia, Colin, Philippe, Lagane, Bernard, Offord, Robin E., Hartley, Oliver, Mosier, Donald E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446584/
https://ncbi.nlm.nih.gov/pubmed/22787219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00353-12
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