Hydroxychloroquine is associated with impaired interferon-alpha and tumor necrosis factor-alpha production by plasmacytoid dendritic cells in systemic lupus erythematosus

INTRODUCTION: Plasmacytoid dendritic cells (pDCs) constitutively express two members of the Toll-like receptor (TLR) family, TLR-9 and TLR-7, through which they can be stimulated to produce high levels of interferon (IFN)-α, a key mediator of the pathogenesis of systemic lupus erythematosus (SLE). G...

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Bibliografiske detaljer
Main Authors: Sacre, Karim, Criswell, Lindsey A, McCune, Joseph M
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446541/
https://ncbi.nlm.nih.gov/pubmed/22734582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3895
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