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The effects of oxygen tension and antiaging factor Klotho on Wnt signaling in nucleus pulposus cells

INTRODUCTION: The goals of this study were to examine the oxemic regulation of Wnt signaling to explore whether Wnt signaling accelerates the age-related degeneration of nucleus pulposus cells, and if so, to define the mechanism underlying this effect. We investigated the expression of Klotho, a new...

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Detalhes bibliográficos
Main Authors: Hiyama, Akihiko, Arai, Fumiyuki, Sakai, Daisuke, Yokoyama, Katsuya, Mochida, Joji
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446482/
https://ncbi.nlm.nih.gov/pubmed/22551380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3830
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