Levels of adiponectin, a marker for PPAR-gamma activity, correlate with skin fibrosis in systemic sclerosis: potential utility as biomarker?

INTRODUCTION: Progressive fibrosis in systemic sclerosis (SSc) is linked to aberrant transforming growth factor beta (TGF-beta) signaling. Peroxisome proliferator-activated receptor gamma (PPAR-gamma) blocks fibrogenic TGF-beta responses in vitro and in vivo. Reduced expression and function of PPAR-...

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Bibliografiske detaljer
Main Authors: Lakota, Katja, Wei, Jun, Carns, Mary, Hinchcliff, Monique, Lee, Jungwha, Whitfield, Michael L, Sodin-Semrl, Snezna, Varga, John
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446479/
https://ncbi.nlm.nih.gov/pubmed/22548780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3827
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