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Enhanced RAD21 cohesin expression confers poor prognosis in BRCA2 and BRCAX, but not BRCA1 familial breast cancers

INTRODUCTION: The RAD21 gene encodes a key component of the cohesin complex, which is essential for chromosome segregation, and together with BRCA1 and BRCA2, for high-fidelity DNA repair by homologous recombination. Although its expression correlates with early relapse and treatment resistance in s...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Yan, Max, Xu, Huiling, Waddell, Nic, Shield-Artin, Kristy, Haviv, Izhak, McKay, Michael J, Fox, Stephen B
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: BioMed Central 2012
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446404/
https://ncbi.nlm.nih.gov/pubmed/22537934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3176
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