Comparable frequency of BRCA1, BRCA2 and TP53 germline mutations in a multi-ethnic Asian cohort suggests TP53 screening should be offered together with BRCA1/2 screening to early-onset breast cancer patients

INTRODUCTION: Germline TP53 mutations cause an increased risk to early-onset breast cancer in Li-Fraumeni syndrome (LFS) families and the majority of carriers identified through breast cancer cohorts have LFS or Li-Fraumeni-like (LFL) features. However, in Asia and in many low resource settings, it...

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Main Authors: Lee, Daphne SC, Yoon, Sook-Yee, Looi, Lai Meng, Kang, Peter, Kang, In Nee, Sivanandan, Kavitta, Ariffin, Hany, Thong, Meow Keong, Chin, Kin Fah, Mohd Taib, Nur Aishah, Yip, Cheng-Har, Teo, Soo-Hwang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446401/
https://ncbi.nlm.nih.gov/pubmed/22507745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3172
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