Phosphorylated and sumoylation-deficient progesterone receptors drive proliferative gene signatures during breast cancer progression

INTRODUCTION: Progesterone receptors (PR) are emerging as important breast cancer drivers. Phosphorylation events common to breast cancer cells impact PR transcriptional activity, in part by direct phosphorylation. PR-B but not PR-A isoforms are phosphorylated on Ser294 by mitogen activated protein...

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Main Authors: Knutson, Todd P, Daniel, Andrea R, Fan, Danhua, Silverstein, Kevin AT, Covington, Kyle R, Fuqua, Suzanne AW, Lange, Carol A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446358/
https://ncbi.nlm.nih.gov/pubmed/22697792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3211
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