Preclinical and clinical studies of estrogen deprivation support the PDGF/Abl pathway as a novel therapeutic target for overcoming endocrine resistance in breast cancer

INTRODUCTION: The majority of breast tumors at primary diagnosis are estrogen receptor positive (ER+). Estrogen (E) mediates its effects by binding to the ER. Therapies targeting the estrogenic stimulation of tumor growth reduce mortality from ER+ breast cancer. However, resistance remains a major c...

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Bibliografische gegevens
Hoofdauteurs: Weigel, Marion T, Ghazoui, Zara, Dunbier, Anita, Pancholi, Sunil, Dowsett, Mitch, Martin, Lesley-Ann
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2012
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446341/
https://ncbi.nlm.nih.gov/pubmed/22608253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3191
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