Mediation of Drosophila autosomal dosage effects and compensation by network interactions

BACKGROUND: Gene dosage change is a mild perturbation that is a valuable tool for pathway reconstruction in Drosophila. While it is often assumed that reducing gene dose by half leads to two-fold less expression, there is partial autosomal dosage compensation in Drosophila, which may be mediated by...

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Detalhes bibliográficos
Main Authors: Malone, John H, Cho, Dong-Yeon, Mattiuzzo, Nicolas R, Artieri, Carlo G, Jiang, Lichun, Dale, Ryan K, Smith, Harold E, McDaniel, Jennifer, Munro, Sarah, Salit, Marc, Andrews, Justen, Przytycka, Teresa M, Oliver, Brian
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446302/
https://ncbi.nlm.nih.gov/pubmed/22531030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2012-13-4-r28
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