Mammalian tissues defective in nonsense-mediated mRNA decay display highly aberrant splicing patterns

BACKGROUND: Nonsense-mediated mRNA decay (NMD) affects the outcome of alternative splicing by degrading mRNA isoforms with premature termination codons. Splicing regulators constitute important NMD targets; however, the extent to which loss of NMD causes extensive deregulation of alternative splicin...

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Detalhes bibliográficos
Main Authors: Weischenfeldt, Joachim, Waage, Johannes, Tian, Geng, Zhao, Jing, Damgaard, Inge, Jakobsen, Janus Schou, Kristiansen, Karsten, Krogh, Anders, Wang, Jun, Porse, Bo T
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446288/
https://ncbi.nlm.nih.gov/pubmed/22624609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2012-13-5-r35
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