MITOCHONDRIAL GSH DETERMINES THE TOXIC OR THERAPEUTIC POTENTIAL OF SUPEROXIDE SCAVENGING IN STEATOHEPATITIS

BACKGROUND & AIM: Steatohepatitis (SH) is associated with mitochondrial dysfunction and superoxide overgeneration, which can be converted into H(2)O(2) by SOD2. Since mitochondrial GSH (mGSH) plays a critical role in H(2)O(2) reduction, we explored the interplay between superoxide, H(2)O(2) and...

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Autori principali: von Montfort, Claudia, Matias, Núria, Fernandez, Anna, Fucho, Raquel, de la Rosa, Laura Conde, Martinez-Chantar, Maria Luz, Mato, José M., Machida, Keigo, Tsukamoto, Hidekazu, Murphy, Michael P., Mansouri, Abdellah, Kaplowitz, Neil, Garcia-Ruiz, Carmen, Fernandez-Checa, Jose C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3445734/
https://ncbi.nlm.nih.gov/pubmed/22687340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2012.05.024
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