Matching biochemical and functional efficacies confirm ZIP as a potent competitive inhibitor of PKMζ in neurons

PKMζ is an autonomously active, atypical protein kinase C (aPKC) isoform that is both necessary and sufficient for maintaining long-term potentiation (LTP) and long-term memory. The myristoylated ζ-pseudosubstrate peptide, ZIP, potently inhibits PKMζ biochemically in vitro, within cultured cells, an...

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Autori principali: Yao, Yudong, Shao, Charles, Jothianandan, Desingarao, Tcherepanov, Andrew, Shouval, Harel, Sacktor, Todd Charlton
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3445653/
https://ncbi.nlm.nih.gov/pubmed/22846225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2012.07.018
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