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Matching biochemical and functional efficacies confirm ZIP as a potent competitive inhibitor of PKMζ in neurons
PKMζ is an autonomously active, atypical protein kinase C (aPKC) isoform that is both necessary and sufficient for maintaining long-term potentiation (LTP) and long-term memory. The myristoylated ζ-pseudosubstrate peptide, ZIP, potently inhibits PKMζ biochemically in vitro, within cultured cells, an...
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| Glavni autori: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2012
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3445653/ https://ncbi.nlm.nih.gov/pubmed/22846225 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2012.07.018 |
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