Deficiency of Interleukin-15 Enhances Susceptibility to Acetaminophen-Induced Liver Injury in Mice

Hepatocytes have a direct necrotic role in acetaminophen (APAP)-induced liver injury (AILI), prolonged secondary inflammatory response through innate immune cells and cytokines also significantly contributes to APAP hepatotoxicity. Interleukin 15 (IL-15), a multifunction cytokine, regulates the adap...

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Bibliografiske detaljer
Main Authors: Hou, Hsein-San, Liao, Ching-Len, Sytwu, Huey-Kang, Liao, Nan-Shih, Huang, Tien-Yu, Hsieh, Tsai-Yuan, Chu, Heng-Cheng
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3445599/
https://ncbi.nlm.nih.gov/pubmed/23028657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044880
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