Broad and Cross-Clade CD4(+) T-Cell Responses Elicited by a DNA Vaccine Encoding Highly Conserved and Promiscuous HIV-1 M-Group Consensus Peptides

T-cell based vaccine approaches have emerged to counteract HIV-1/AIDS. Broad, polyfunctional and cytotoxic CD4(+) T-cell responses have been associated with control of HIV-1 replication, which supports the inclusion of CD4(+) T-cell epitopes in vaccines. A successful HIV-1 vaccine should also be des...

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Detalhes bibliográficos
Main Authors: Almeida, Rafael Ribeiro, Rosa, Daniela Santoro, Ribeiro, Susan Pereira, Santana, Vinicius Canato, Kallás, Esper Georges, Sidney, John, Sette, Alessandro, Kalil, Jorge, Cunha-Neto, Edecio
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3445454/
https://ncbi.nlm.nih.gov/pubmed/23028895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045267
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