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Patterns and Possible Roles of LINE-1 Methylation Changes in Smoke-Exposed Epithelia

Tobacco smoking and reduced methylation of long interspersed element-1 (LINE-1) are crucial in oral carcinogenesis. 5′UTR of human LINE-1 sequence contains several CpG dinucleotides which are methylated in various proportions (0–100%). Methylation levels of many LINE-1s in cancer were reduced, hypom...

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מידע ביבליוגרפי
Main Authors: Wangsri, Siriporn, Subbalekha, Keskanya, Kitkumthorn, Nakarin, Mutirangura, Apiwat
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3445447/
https://ncbi.nlm.nih.gov/pubmed/23028911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045292
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