Antitumor effects of the investigational selective MEK inhibitor TAK733 against cutaneous and uveal melanoma cell lines

BACKGROUND: TAK733 is a novel allosteric, non-ATP-binding, inhibitor of the BRAF substrates MEK-1/2. METHODS: The growth inhibitory effects of TAK733 were assessed in a panel of 27 cutaneous and five uveal melanoma cell lines genotyped for driver oncogenic mutations. Flow cytometry, Western blots an...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Glavni autori: von Euw, Erika, Atefi, Mohammad, Attar, Narsis, Chu, Connie, Zachariah, Sybil, Burgess, Barry L, Mok, Stephen, Ng, Charles, Wong, Deborah JL, Chmielowski, Bartosz, Lichter, David I, Koya, Richard C, McCannel, Tara A, Izmailova, Elena, Ribas, Antoni
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2012
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3444881/
https://ncbi.nlm.nih.gov/pubmed/22515704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-11-22
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items