Sustained generation of nitric oxide and control of mycobacterial infection requires argininosuccinate synthase 1

Nitric oxide (NO) defends against intracellular pathogens but its synthesis must be regulated due to cell and tissue toxicity. During infection, macrophages import extracellular arginine to synthesize NO, generating the byproduct citrulline. Accumulated intracellular citrulline is thought to fuel ar...

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Detalhes bibliográficos
Main Authors: Qualls, Joseph E., Subramanian, Chitra, Rafi, Wasiulla, Smith, Amber M., Balouzian, Liza, DeFreitas, Ashley A., Shirey, Kari Ann, Reutterer, Benjamin, Kernbauer, Elisabeth, Stockinger, Silvia, Decker, Thomas, Miyairi, Isao, Vogel, Stefanie N., Salgame, Padmini, Rock, Charles O., Murray, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3444824/
https://ncbi.nlm.nih.gov/pubmed/22980328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2012.07.012
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