EGF Receptor is Required for KRAS-induced Pancreatic Tumorigenesis

Initiation of pancreatic ductal adenocarcinoma (PDA) is definitively linked to activating mutations in the KRAS oncogene. However, PDA mouse models show that mutant Kras expression early in development gives rise to a normal pancreas, with tumors forming only after a long latency or pancreatitis ind...

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Auteurs principaux: Ardito, Christine M., Grüner, Barbara M., Takeuchi, Kenneth K., Lubeseder-Martellato, Clara, Teichmann, Nicole, Mazur, Pawel K., DelGiorno, Kathleen E., Carpenter, Eileen S., Halbrook, Christopher J., Hall, Jason C., Pal, Debjani, Briel, Thomas, Herner, Alexander, Trajkovic-Arsic, Marija, Sipos, Bence, Liou, Geou-Yarh, Storz, Peter, Murray, Nicole R., Threadgill, David W., Sibilia, Maria, Washington, M. Kay, Wilson, Carole L., Schmid, Roland M., Raines, Elaine W., Crawford, Howard C., Siveke, Jens T.
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3443395/
https://ncbi.nlm.nih.gov/pubmed/22975374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.07.024
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