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Gating Movement of Acetylcholine Receptor Caught by Plunge-Freezing

The nicotinic acetylcholine (ACh) receptor converts transiently to an open-channel form when activated by ACh released into the synaptic cleft. We describe here the conformational change underlying this event, determined by electron microscopy of ACh-sprayed and freeze-trapped postsynaptic membranes...

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Detalhes bibliográficos
Main Authors: Unwin, Nigel, Fujiyoshi, Yoshinori
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3443390/
https://ncbi.nlm.nih.gov/pubmed/22841691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.07.010
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