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Gating Movement of Acetylcholine Receptor Caught by Plunge-Freezing
The nicotinic acetylcholine (ACh) receptor converts transiently to an open-channel form when activated by ACh released into the synaptic cleft. We describe here the conformational change underlying this event, determined by electron microscopy of ACh-sprayed and freeze-trapped postsynaptic membranes...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Elsevier
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3443390/ https://ncbi.nlm.nih.gov/pubmed/22841691 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.07.010 |
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