The Inhibition of Autophagy Sensitises Colon Cancer Cells with Wild-Type p53 but Not Mutant p53 to Topotecan Treatment

BACKGROUND: Topotecan produces DNA damage that induces autophagy in cancer cells. In this study, sensitising topotecan to colon cancer cells with different P53 status via modulation of autophagy was examined. METHODOLOGY/PRINCIPAL FINDINGS: The DNA damage induced by topotecan treatment resulted in c...

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Bibliographische Detailangaben
Hauptverfasser: Li, Dan-Dan, Sun, Ting, Wu, Xiao-Qi, Chen, Shu-Peng, Deng, Rong, Jiang, Shan, Feng, Gong-Kan, Pan, Jing-Xuan, Zhang, Xiao-Shi, Zeng, Yi-Xin, Zhu, Xiao-Feng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3443203/
https://ncbi.nlm.nih.gov/pubmed/23024792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045058
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