Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2

Many persistent viruses have evolved the ability to subvert MHC class I antigen presentation. Indeed, human cytomegalovirus (HCMV) encodes at least four proteins that down-regulate cell-surface expression of class I. The HCMV unique short (US)2 glycoprotein binds newly synthesized class I molecules...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Gewurz, Benjamin E., Gaudet, Rachelle, Tortorella, Domenico, Wang, Evelyn W., Ploegh, Hidde L., Wiley, Don C.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2001
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC34432/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11391001/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.121172898
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