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Chemical synthesis and X-ray structure of a heterochiral {D-protein antagonist plus vascular endothelial growth factor} protein complex by racemic crystallography

Total chemical synthesis was used to prepare the mirror image (D-protein) form of the angiogenic protein vascular endothelial growth factor (VEGF-A). Phage display against D-VEGF-A was used to screen designed libraries based on a unique small protein scaffold in order to identify a high affinity lig...

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מידע ביבליוגרפי
Main Authors: Mandal, Kalyaneswar, Uppalapati, Maruti, Ault-Riché, Dana, Kenney, John, Lowitz, Joshua, Sidhu, Sachdev S., Kent, Stephen B.H.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3443191/
https://ncbi.nlm.nih.gov/pubmed/22927390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1210483109
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