The Extracellular and Transmembrane Domains of the γC and Interleukin (IL)-13 Receptor α1 Chains, Not Their Cytoplasmic Domains, Dictate the Nature of Signaling Responses to IL-4 and IL-13

Previously, we demonstrated that the γC subunit of type I IL-4 receptor was required for robust tyrosine phosphorylation of the downstream adapter protein, IRS-2, correlating with the expression of genes (ArgI, Retnla, and Chi3l3) characteristic of alternatively activated macrophages. We located an...

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Detalhes bibliográficos
Main Authors: Heller, Nicola M., Qi, Xiulan, Gesbert, Franck, Keegan, Achsah D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442527/
https://ncbi.nlm.nih.gov/pubmed/22829596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.348896
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