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Oncogenic K-Ras Regulates Bioactive Sphingolipids in a Sphingosine Kinase 1-dependent Manner

Sphingosine kinase 1 (SK1) is an important enzyme involved in the production of the bioactive lipid sphingosine 1-phosphate (S1P). SK1 is overexpressed in many forms of cancer, however, the contribution of SK1 to cancer progression is still unclear. One of the best characterized mutations found in s...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Gault, Christopher R., Eblen, Scott T., Neumann, Carola A., Hannun, Yusuf A., Obeid, Lina M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2012
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442513/
https://ncbi.nlm.nih.gov/pubmed/22833671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.385765
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