Translocation of sickle cell erythrocyte microRNAs into Plasmodium falciparum inhibits parasite translation and contributes to malaria resistance

Erythrocytes carrying a variant hemoglobin allele (HbS), which causes sickle cell disease, resist infection by the malaria parasite Plasmodium falciparum. The molecular basis of this resistance, which has long been recognized as multifactorial, remains incompletely understood. Here we show that the...

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Auteurs principaux: LaMonte, Gregory, Philip, Nisha, Reardon, Joseph, Lacsina, Joshua R., Majoros, William, Chapman, Lesley, Thornburg, Courtney D., Telen, Marilyn J., Ohler, Uwe, Nicchitta, Christopher V., Haystead, Timothy, Chi, Jen-Tsan
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442262/
https://ncbi.nlm.nih.gov/pubmed/22901539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2012.06.007
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