Ogt-Dependent X-Chromosome-Linked Protein Glycosylation Is a Requisite Modification in Somatic Cell Function and Embryo Viability

The Ogt gene encodes a glycosyltransferase that links N-acetylglucosamine to serine and threonine residues (O-GlcNAc) on nuclear and cytosolic proteins. Efforts to study a mammalian model of Ogt deficiency have been hindered by the requirement for this X-linked gene in embryonic stem cell viability,...

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Detalhes bibliográficos
Main Authors: O'Donnell, Niall, Zachara, Natasha E., Hart, Gerald W., Marth, Jamey D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC344186/
https://ncbi.nlm.nih.gov/pubmed/14749383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.4.1680-1690.2004
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