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Two Cyclin-Dependent Kinases Promote RNA Polymerase II Transcription and Formation of the Scaffold Complex

Three cyclin-dependent kinases, CDK7, -8, and -9, are specifically involved in transcription by RNA polymerase II (Pol II) and target the Pol II C-terminal domain (CTD). The role of CDK7 and CDK8 kinase activity in transcription has been unclear, with CDK7 shown to have variable effects on transcrip...

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Detalhes bibliográficos
Main Authors: Liu, Ying, Kung, Charles, Fishburn, James, Ansari, Aseem Z., Shokat, Kevan M., Hahn, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC344185/
https://ncbi.nlm.nih.gov/pubmed/14749387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.4.1721-1735.2004
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