Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation

BACKGROUND: T cell activation is associated with a rapid increase in intracellular fructose-2,6-bisphosphate (F2,6BP), an allosteric activator of the glycolytic enzyme, 6-phosphofructo-1-kinase. The steady state concentration of F2,6BP in T cells is dependent on the expression of the bifunctional 6-...

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Autors principals: Telang, Sucheta, Clem, Brian F, Klarer, Alden C, Clem, Amy L, Trent, John O, Bucala, Richard, Chesney, Jason
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3441391/
https://ncbi.nlm.nih.gov/pubmed/22591674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-10-95
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