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Fitness conferred by replaced amino acids declines with time
The fitness landscape of a locus, the array of fitnesses conferred by its alleles, can be affected by allele replacements at other loci, in the presence of epistatic interactions between loci. In a pair of diverging homologous proteins, the initially high probability that an amino acid replacement i...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The Royal Society
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3440982/ https://ncbi.nlm.nih.gov/pubmed/22628094 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsbl.2012.0356 |
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