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Changing preferences: deformation of single position amino acid fitness landscapes and evolution of proteins

The fitness landscape—the function that relates genotypes to fitness—and its role in directing evolution are a central object of evolutionary biology. However, its huge dimensionality precludes understanding of even the basic aspects of its shape. One way to approach it is to ask a simpler question:...

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Vydáno v:Biol Lett
Hlavní autor: Bazykin, Georgii A.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Royal Society 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4650171/
https://ncbi.nlm.nih.gov/pubmed/26445980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsbl.2015.0315
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