Valproate inhibits colon cancer growth through cell cycle modification in vivo and in vitro

Valproate (VPA) is a well-characterized histone deacetylase inhibitor with anti-neoplastic properties. We analyzed the growth blocking effects and the molecular mode of action of this compound in colorectal cancer cells in vitro and in vivo. Caco-2, SW-480, CX-1 or WIDR cell lines were exposed to VP...

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Detalhes bibliográficos
Main Authors: STREY, CHRISTOPH W., SCHAMELL, LEA, OPPERMANN, ELSIE, HAFERKAMP, AXEL, BECHSTEIN, WOLF O., BLAHETA, ROMAN A.
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3440661/
https://ncbi.nlm.nih.gov/pubmed/22977502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/etm.2011.202
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