Ecotin-like serine peptidase inhibitor ISP1 of Leishmania major plays a role in flagellar pocket dynamics and promastigote differentiation

Leishmania ISPs are ecotin-like natural peptide inhibitors of trypsin-family serine peptidases, enzymes that are absent from the Leishmania genome. This led to the proposal that ISPs inhibit host serine peptidases and we have recently shown that ISP2 inhibits neutrophil elastase, thereby enhancing p...

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Detalhes bibliográficos
Main Authors: Morrison, Lesley S, Goundry, Amy, Faria, Marilia S, Tetley, Laurence, Eschenlauer, Sylvain C, Westrop, Gareth D, Dostalova, Anna, Volf, Petr, Coombs, Graham H, Lima, Ana Paula C A, Mottram, Jeremy C
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3440592/
https://ncbi.nlm.nih.gov/pubmed/22486816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1462-5822.2012.01798.x
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