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Enhanced Th17 differentiation and aggravated arthritis in IEX-1-deficient mice by mitochondrial ROS-mediated signaling

CD4(+) T helper (Th)1 and Th17 cells both can cause autoimmune diseases either alone or collaboratively, if left unchecked. However, what determines the dominant Th effector phenotype in a specific autoimmune disease remains ill understood. Our present investigation shows that null mutation of immed...

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Bibliografski detalji
Glavni autori: Zhi, Liang, Ustyugova, Irina V., Chen, Xinyuan, Zhang, Qi, Wu, Mei X.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3440304/
https://ncbi.nlm.nih.gov/pubmed/22798682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200528
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