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Ultra-Rapid Absorption of Recombinant Human Insulin Induced by Zinc Chelation and Surface Charge Masking

BACKGROUND: In order to enhance the absorption of insulin following subcutaneous injection, excipients were selected to hasten the dissociation rate of insulin hexamers and reduce their tendency to reassociate postinjection. A novel formulation of recombinant human insulin containing citrate and dis...

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Autores principales: Pohl, Roderike, Hauser, Robert, Li, Ming, De Souza, Errol, Feldstein, Robert, Seibert, Richard, Ozhan, Koray, Kashyap, Nandini, Steiner, Solomon
Formato: Artigo
Lenguaje:Inglês
Publicado: Diabetes Technology Society 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3440144/
https://ncbi.nlm.nih.gov/pubmed/22920799
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