A Review of a Family of Ultra-Rapid-Acting Insulins: Formulation Development

This review summarizes the clinical development of a family of ultra-rapid-acting recombinant human insulin formulations. These formulations use ethylenediaminetetraacetic acid (EDTA) to chelate zinc and thereby destabilize insulin hexamers. In addition, insulin monomer surface charges are chemicall...

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Main Authors: Krasner, Alan, Pohl, Roderike, Simms, Patrick, Pichotta, Philip, Hauser, Robert, De Souza, Errol
Format: Artigo
Jezik:Inglês
Izdano: Diabetes Technology Society 2012
Teme:
Symposium
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3440148/
https://ncbi.nlm.nih.gov/pubmed/22920803
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