Zinc Finger Protein Designed to Target 2-Long Terminal Repeat Junctions Interferes with Human Immunodeficiency Virus Integration

Integration of the human immunodeficiency virus type 1 (HIV-1) genome into the host chromosome is a vital step in the HIV life cycle. The highly conserved cytosine–adenine (CA) dinucleotide sequence immediately upstream of the cleavage site is crucial for integrase (IN) activity. As this viral enzym...

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Detalhes bibliográficos
Main Authors: Sakkhachornphop, Supachai, Barbas, Carlos F., Keawvichit, Rassamee, Wongworapat, Kanlaya, Tayapiwatana, Chatchai
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2012
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3440019/
https://ncbi.nlm.nih.gov/pubmed/22429108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2011.124
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