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Inhibition of Escherichia coli viability by external guide sequences complementary to two essential genes

Narrow spectrum antimicrobial activity has been designed to reduce the expression of two essential genes, one coding for the protein subunit of RNase P (C5 protein) and one for gyrase (gyrase A). In both cases, external guide sequences (EGS) have been designed to complex with either mRNA. Using the...

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Autori principali: McKinney, Jeffrey, Guerrier-Takada, Cecilia, Wesolowski, Donna, Altman, Sidney
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC34400/
https://ncbi.nlm.nih.gov/pubmed/11381134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.121180398
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