A phase I clinical trial of adoptive transfer of folate receptor-alpha redirected autologous T cells for recurrent ovarian cancer

PURPOSE: In spite of increased rates of complete response to initial chemotherapy, most patients with advanced ovarian cancer relapse and succumb to progressive disease. RATIONALE: Genetically reprogrammed, patient-derived chimeric antigen receptor (CAR)-T lymphocytes with the ability to recognize p...

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Bibliographic Details
Main Authors: Kandalaft, Lana E, Powell, Daniel J, Coukos, George
Format: Artigo
Language:Inglês
Published: BioMed Central 2012
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3439340/
https://ncbi.nlm.nih.gov/pubmed/22863016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-10-157
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