A quantitative model of the initiation of DNA replication in Saccharomyces cerevisiae predicts the effects of system perturbations

BACKGROUND: Eukaryotic cell proliferation involves DNA replication, a tightly regulated process mediated by a multitude of protein factors. In budding yeast, the initiation of replication is facilitated by the heterohexameric origin recognition complex (ORC). ORC binds to specific origins of replica...

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Main Authors: Gidvani, Rohan D, Sudmant, Peter, Li, Grace, DaSilva, Lance F, McConkey, Brendan J, Duncker, Bernard P, Ingalls, Brian P
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2012
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3439281/
https://ncbi.nlm.nih.gov/pubmed/22738223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-6-78
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