Identification of a Novel Pathway of Transforming Growth Factor-β1 Regulation by Extracellular NAD(+) in Mouse Macrophages: IN VITRO AND IN SILICO STUDIES

Extracellular β-nicotinamide adenine dinucleotide (NAD(+)) is anti-inflammatory. We hypothesized that NAD(+) would modulate the anti-inflammatory cytokine Transforming Growth Factor (TGF)-β1. Indeed, NAD(+) led to increases in both active and latent cell-associated TGF-β1 in RAW 264.7 mouse macropha...

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Detalhes bibliográficos
Main Authors: Zamora, Ruben, Azhar, Nabil, Namas, Rajaie, Metukuri, Mallikarjuna R., Clermont, Thierry, Gladstone, Chase, Namas, Rami A., Hermus, Linda, Megas, Cristina, Constantine, Gregory, Billiar, Timothy R., Fink, Mitchell P., Vodovotz, Yoram
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3438933/
https://ncbi.nlm.nih.gov/pubmed/22829588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.344309
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