Structure and Catalytic Mechanism of 3-Ketosteroid-Δ4-(5α)-dehydrogenase from Rhodococcus jostii RHA1 Genome

3-Ketosteroid Δ4-(5α)-dehydrogenases (Δ4-(5α)-KSTDs) are enzymes that introduce a double bond between the C4 and C5 atoms of 3-keto-(5α)-steroids. Here we show that the ro05698 gene from Rhodococcus jostii RHA1 codes for a flavoprotein with Δ4-(5α)-KSTD activity. The 1.6 Å resolution crystal structu...

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Библиографические подробности
Главные авторы: van Oosterwijk, Niels, Knol, Jan, Dijkhuizen, Lubbert, van der Geize, Robert, Dijkstra, Bauke W.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2012
Предметы:
Protein Structure and Folding
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3438930/
https://ncbi.nlm.nih.gov/pubmed/22833669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.374306
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