Survival and risk of relapse of acute lymphoblastic leukemia in a Mexican population is affected by dihydrofolate reductase gene polymorphisms

Dihydrofolate reductase (DHFR) is the major target of methotrexate, a key component in childhood acute lymphoblastic leukemia (ALL) treatment. Polymorphisms in the gene coding for DHFR have been associated with adverse event treatment. This study evaluated the effect of the -A317G and C829T polymorp...

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Hauptverfasser: GÓMEZ-GÓMEZ, YAZMÍN, ORGANISTA-NAVA, JORGE, SAAVEDRA-HERRERA, MÓNICA VIRGINIA, RIVERA-RAMÍREZ, ANA BERTHA, TERÁN-PORCAYO, MARCO ANTONIO, DEL CARMEN ALARCÓN-ROMERO, LUZ, ILLADES-AGUIAR, BERENICE, LEYVA-VÁZQUEZ, MARCO ANTONIO
Format: Artigo
Sprache:Inglês
Veröffentlicht: D.A. Spandidos 2012
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3438609/
https://ncbi.nlm.nih.gov/pubmed/22969948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/etm.2012.447
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