JNK3 perpetuates metabolic stress induced by Abeta peptides

Although Aβ peptides are causative agents in Alzheimer's disease (AD), the underlying mechanisms are still elusive. We report that Aβ42 induces a translational block by activating AMPK, thereby inhibiting the mTOR pathway. This translational block leads to widespread ER stress, which activates...

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Bibliografische gegevens
Hoofdauteurs: Yoon, Sung Ok, Park, Dong Ju, Ryu, Jae Cheon, Ozer, Hatice Gulcin, Tep, Chhavy, Shin, Yong Jae, Lim, Tae Hee, Pastorino, Lucia, Kunwar, Ajaya J., Walton, James C., Nagahara, Alan H., Lu, Kun Ping, Nelson, Randy J., Tuszynski, Mark H., Huang, Kun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3438522/
https://ncbi.nlm.nih.gov/pubmed/22958823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2012.06.024
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