Pharmacokinetics, pharmacodynamics, and safety of clevidipine after prolonged continuous infusion in subjects with mild to moderate essential hypertension

PURPOSE: Clevidipine is a rapidly-acting intravenous dihydropyridine antihypertensive acting via calcium channel blockade. This was a randomized, single-blind, parallel-design study of a 72-h continuous clevidipine infusion. METHOD: Doses of 2, 4, 8, or 16.0 mg/h or placebo were evaluated in 61 subj...

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Detalhes bibliográficos
Main Authors: Smith, William B., Marbury, Thomas C., Komjathy, Steven F., Sumeray, Mark S., Williams, Gregory C., Hu, Ming-yi, Mould, Diane R.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2012
Assuntos:
Pharmacodynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3438395/
https://ncbi.nlm.nih.gov/pubmed/22457015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-012-1260-3
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