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Transcriptional Regulation of BACE1, the β-Amyloid Precursor Protein β-Secretase, by Sp1

Proteolytic processing of the β-amyloid precursor protein (APP) at the β site is essential to generate Aβ. BACE1, the major β-secretase involved in cleaving APP, has been identified as a type 1 membrane-associated aspartyl protease. We have cloned a 2.1-kb fragment upstream of the human BACE1 gene a...

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Publicado no:Mol Cell Biol
Principais autores: Christensen, Michelle A., Zhou, Weihui, Qing, Hong, Lehman, Anna, Philipsen, Sjaak, Song, Weihong
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2004
Assuntos:
Transcriptional Regulation
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC343820/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14701757/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.2.865-874.2004
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